Angiotensin II (3-8), human is a less effective agonist at the angiotensin AT1 receptor.

患有CCH的大鼠的大脑中Aβ42、p-tau和促炎细胞因子的水平比对照组高。Ang IV的注入显著降低了患CCH的大鼠大脑中促炎细胞因子的表达。同时，Ang IV引起的促炎细胞因子水平的降低被divalinal-Ang IV逆转。在治疗期间，大鼠的SBP并没有显著改变[1]。

Eight weeks after bilateral CCA ligation surgery, rats were anaesthetized with 10% chloral hydrate and placed in a stereotactic frame. The scalp was reflected under sterile surgical conditions. A brain-infusion cannula coupled via vinyl tubing to an osmotic pump was implanted into the third cerebral ventricle by surgeons who were blinded to the experimental groups. Osmotic pumps were placed subcutaneously between the scapulae and used to infuse two doses of Ang IV (20 nM, 0.15 μl/h and 100 nM, 0.15 μl/h), divalinal-Ang IV (500 nM, 0.15 μl/h) or aCSF (0.15 μl/h) into the third cerebral ventricle, lasting for six weeks. Following this surgery, the wounds were carefully closed with sutures[1]